EDTA is a synthetic amino acid that has proven to be the best broad-based heavy metal chelator with very few adverse effects. The half-life of EDTA in the body, via the topical route of administration, can be up to eight hours, and is excreted through feces and urine within 24 hours; almost none of the Kelacream EDTA is metabolized. Since the vast majority of the EDTA will be broken down and not utilized when taken orally, the topical administration is more effective. This allows it to bypass the gastro-intestinal tract all together, resulting in a very high utilization rate. Topical administration delivery also results in a majority of the EDTA bypassing the liver and kidneys on the first pass, putting less stress on these organs and allowing the EDTA to remain in the body longer, extending the binding effect with the harmful metals. It is always best to consult a practitioner when taking Kelacream and all nutritional supplements.